a. Genetic polymorphism in Drug metabolism: Cytochrome P-450 Isoenzymes.
Curriculum Unit: 7. Pharmacogenetics
Overview & Academic Context
This study module covers "Genetic polymorphism in Drug metabolism: Cytochrome P-450 Isoenzymes.", an integral component of the Year 5 Doctor of Pharmacy (Pharm.D) curriculum under Clinical Pharmacokinetics & Pharmacotherapeutic Drug Monitoring (Pharmacogenetics). Designed for clinical pharmacy scholars, the syllabus emphasizes mechanistic understanding, clinical relevance, and high-yield examination competencies.
Core Study Concepts
Learning Objectives
Upon reviewing this syllabus topic, Pharm.D students are expected to demonstrate proficiency in:
- Understand the foundational etiology, classification, and clinical significance of Genetic polymorphism in Drug metabolism: Cytochrome P-450 Isoenzymes..
- Analyze the underlying pathophysiology and disease manifestations relevant to Pharmacogenetics.
- Evaluate evidence-based pharmacotherapeutic management, therapeutic drug choices, and dosage individualization.
- Identify critical patient monitoring parameters, adverse drug reactions (ADRs), and drug-drug interactions.
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Curriculum References & Recommended Texts
Standard literature and institutional sources for Clinical Pharmacokinetics & Pharmacotherapeutic Drug Monitoring:
- [1]Pharmacy Council of India (PCI) Pharm.D Curriculum Syllabus Guidelines
- [2]Pharmacotherapy: A Pathophysiologic Approach (Joseph T. DiPiro et al.)
- [3]Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drugs
- [4]Standard National and International Clinical Practice Guidelines (WHO, ACC/AHA, IDSA)